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In the current study two methods are evaluated for predicting the compressive strength of concrete containing metakaolin. Adaptive neuro-fuzzy inference system (ANFIS) model and stepwise regression (SR) model are developed as a reliable modeling method for simulating and predicting the compressive strength of concrete containing metakaolin at the different ages. The required data in training and testing state obtained from a reliable data base. Then, a comparison has been made between proposed ANFIS model and SR model to have an idea about the predictive power of these methods.