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This paper deals with the optimization of reinforced concrete (RC) structures under earthquake loads by introducing a simple methodology. One of the most important problems in the design of RC structures is the existing of various design scenarios that all of them satisfy design constraints. Despite of the steel structures, a large number of design candidates due to a large number of design variables can be utilized. Doubtless, the economical and practical aspects are two effective parameters on accepting a design candidate. As such, in this paper the conventional design process that uses a trial and error process is replaced with an automated process using optimization technique. Also, the cost of construction is selected as an objective function in the automated process. A real valued model of particle swarm optimization (PSO) algorithm is utilized to perform the optimization process. Design constraints conform to the ACI318-08 code and standard 2800-code recommendations. Three ground motion records modified based on Iranian Design Spectrum is considered as earthquake excitations. Moreover, to reveal the effectiveness and robustness of the presented methodology, for example, a three-bay eighteen-story RC frame is optimized against the combination of gravity and earthquake loads. The entire process is summarized in a computer programming using a link between MATLAB platform and OpenSEES as open source object-oriented software.