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Showing 3 results for Reddy

S. Giridhar Reddy, A. Thakur,
Volume 15, Issue 3 (September 2018)

Biodegradable polymer blends are prepared by solution casting method by mixing Sodium alginate (SA) and Lignosulphonic acid (LS) biodegradable polymers. In order to investigate for controlled drug delivery the thermal stability of polymer blends are the primary requirements because they should be stable in aqueous medium. The polymer blends are studied using thermogravimetric analysis. The TGA data are used to analyze degradation temperature and energy of activation using ‘Horowitz and Metzger’ an approximate integral method. The energy of activation reveals that blends are stable as compared to their polymers.
A. Thakur, G. Reddy,
Volume 17, Issue 3 (September 2020)

Mercury, one of the common pollutants in water, is known to affect human health adversely upon exposure. It is released in water not only by various natural processes but also by human activities. Methods developed so far for the detection of mercuric ions in water have limitations like sensitivity range, complex setup, skillful operation etc. Silver nanoparticles, due to unique properties, have been explored by researchers to develop better detection systems.  Stable silver nanoparticles can be easily synthesized by methods of green chemistry, its reaction with mercuric ion can be easily observed by changes in color and UV-Vis spectra. The absorbance data from UV-Vis spectra can also be used in quantifying mercury concentration. In this paper, stable silver nanoparticles synthesized using silver nitrate as precursor, sodium lignosulphonate (LS) as reducing and stabilizing agent under microwave radiation are explored for detection of mercuric ions in water. Formation of AgNP was confirmed by UV-Vis band at 403.5nm. The intensity of this band showed a proportional decrease with increasing Hg+2 concentration. Hg+2 ions were detected by a distinct color change at higher concentration of Hg+2 also.  The limit of detection (LOD) calculated from the observed absorbance data to be 0.7 ppm.

S. Giridhar Reddy,
Volume 19, Issue 2 (June-Biomaterials Special Issue- 2022)

Sodium alginate (SA), brown seaweed algae, and Lignosulphonic acid (LS), a plant product, are biodegradable polymers extensively investigated for drug-controlled release. The Hydroxychloroquine sulphate (HCQ) drug, an antimalarial drug, was extensively used in the initial periods of COVID situations. The HCQ drug release from SALS beads is investigated for its control release in a simulated medium (pH1.2 and pH7.4) using different crosslinking agents such as Calcium chloride, Barium chloride and Aluminum chloride. The HCQ release has better controlled in Barium crosslinked beads. They are found to be relatively intact and stable and release the drug for more than 180 minutes in the simulated medium. Further drug entrapment studies prove very high for Ba crosslinked SALS beads. Whereas Aluminum crosslinked beads showed, inferior crosslinking and drug retention in beads is very low and starts degrading in simulated fluids. Drug release kinetics were analyzed using various kinetic model equations to discuss the order of reaction and drug-polymer mechanism.  FT-IR investigations of beads show chemical interactions between crosslinking ion and alginate blends.

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